#Aspirin poisoning antidote full#

Based on this information, the patient was subsequently treated with a single dose of activated charcoal (50 g activated charcoal mixed in water) and hyperhydration (2× Baxter Hartmann Viaflo 500 mL and 1× Baxter Hartmann NaCl 0.09% 1000 mL). The patient woke up around 2 pm, at which point he decided to call the emergency services. The patient had taken different types of ASA (regular and enteric coated in unknown distribution) tablets.

All tablets had been purchased in various pharmacies by the patient several days before the intake. During the anamnesis, the patient revealed the ingestion of 120 tablets of aspirin (acetylsalicylic acid or ASA) 500 mg (total drug intake of 60 g) from the early morning to 11 am on the same day, before he fell asleep.

On the arrival at the ED, the patient was awake, alert, and oriented with a Glasgow Coma Scale of 15/15. Hereby, we report the case of a 50‐year‐old man that was admitted around 4 pm in the emergency department (ED) of Saint‐Luc hospital in the context of a suicide attempt. The report below outlines the case of a 50‐year‐old man admitted to the emergency department (ED) of our hospital within the context of a “suicidal attempt by taking a considerable amount of aspirin.” The use of clinical laboratory tests appeared to be beneficial in managing intoxication and not only improved the treatment but also positively impacted the patient's length of stay at the hospital, avoiding any organ damage. This is because clinical care given to patients depends on salicylate dosage, monitoring of renal function, plasma metabolic acidosis and/or alkalosis, plasma bicarbonate, and C‐reactive protein (CRP). To improve and control the intoxication and to limit organ damage, the 24/7 clinical (toxicology) laboratory appears to be crucial. The management of salicylate intoxication has remained relatively unchanged in the past few decades, with a lack of direct antidote making the treatment more challenging. Salicylate intoxication is one of the most commonly reported over the counter (OTC) drug intoxications. Activated Charcoal for Acute Poisoning: One Toxicologist’s Journey. Extracorporeal Treatment for Salicylate Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup.

Juurlink DN, Gosselin S, Kielstein JT, et al.

An evidence based flowchart to guide the management of acute salicylate (aspirin) overdose.

#Aspirin poisoning antidote full#

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Jan Schlebes (medical editor, is a shareholder in Fresenius SE & Co KGaA). All of the relevant financial relationships listed for the following individuals have been mitigated: $Contributor Disclosures - Salicylate poisoning.Guidance Document: Management Priorities in Salicylate Toxicity. American College of Medical Toxicology.Continuous cardiac monitoring, continuous pulse oximetry, frequent neurological checksĪcute management checklist for salicylate poisoning.Serum salicylates (until consistently Continuous bicarbonate in D5W to achieve and maintain urine alkalization.Consider bicarbonate loading dose, especially if arterial pH The ingested aspirin dose is known to be > 500 mg/kg.Salicylate combinations with other substances (like opioids) can lead to mixed intoxications that require specific management (e.g., naloxone). Intubating patients with salicylate poisoning is dangerous! If intubation is required, extra care should be taken to maximize minute ventilation, as there is a high risk of worsening acidosis and death. Serum salicylates > 90 mg/dL ( > 80 mg/dL if renal function impaired) or arterial pH ≤ 7.2 despite supportive care.Serum salicylates > 100 mg/dL ( > 90 mg/dL if renal function impaired).Indications for hemodialysis in salicylate poisoning Indications for intubation in salicylate poisoning Maximize minute ventilation (e.g., at least 8–10 mL/kg/breath).Administer bicarbonate prior to intubation.Evaluate the need for intubation but avoid intubation, if possible.For symptomatic patients: Consult ICU, nephrology, and toxicology.Assess the severity of salicylate poisoning (see salicylate poisoning severity above).